GTPase-activating proteins (GAPs) function as negative regulators of GTPase proteins, essentially turning them "off."
Here's a breakdown of their function:
- Regulating GTPase Activity: GAPs accelerate the conversion of GTPase proteins from their active, GTP-bound state to their inactive, GDP-bound state. As stated in the provided reference, GAPs "promote the conversion of the active GTPase-GTP form to the GTPase-GDP form."
- Indirect Involvement in Cellular Processes: Due to their ability to regulate GTPases, GAPs are involved, either directly or indirectly, in various cell processes.
| Feature | Description |
|---|---|
| Primary Function | Inactivate GTPase proteins |
| Mechanism | Promotes GTP hydrolysis, converting GTP to GDP |
| Result | Switches GTPase from an active to inactive state |
| Cellular Impact | Influences diverse cellular processes through GTPase regulation (directly or indirectly) |
In simple terms, think of GTPases as molecular switches. GAPs act like "off" switches, ensuring that GTPases don't stay active for too long, thus carefully controlling cell signaling and other essential functions.
