Red blood cells (RBCs) are anaerobic. They rely solely on anaerobic glycolysis for energy.
RBC Energy Production: Anaerobic Glycolysis
Unlike most eukaryotic cells, RBCs don't use mitochondria for oxidative phosphorylation. Instead, they generate energy through anaerobic glycolysis. This means they break down glucose without using oxygen. The reference states that "RBC rely solely on anaerobic glycolysis (rather than oxidative phosphorylation carried out by mitochondria) for their energy metabolism." This unique feature is essential for their function:
- Oxygen Transport: Avoiding oxygen consumption themselves allows RBCs to efficiently transport oxygen to other tissues.
- No Mitochondria: The absence of mitochondria maximizes space for hemoglobin, the oxygen-carrying protein.
In summary, RBCs function without oxygen, relying on anaerobic glycolysis for their energy needs.
