Yes, girls generally have softer skin than boys. This is primarily due to hormonal differences. Estrogen, a hormone present in higher levels in women, contributes to thinner skin and increased subcutaneous fat deposits, resulting in a softer texture. Additionally, men's skin tends to be thicker and tougher due to the influence of testosterone.
While this is a general observation, individual differences exist. Genetics, lifestyle choices, and skincare habits all play a role in skin softness.