Pustulosis is a highly inflammatory skin condition characterized by the appearance of numerous pustules – fluid-filled blisters. These pustules typically appear on the palms of the hands and/or the soles of the feet, although other forms can affect the entire body.
Types of Pustulosis
Several types of pustulosis exist, each with varying characteristics and causes:
- Palmoplantar Pustulosis (PPP): A common, chronic inflammatory condition primarily affecting the palms and soles. This is also sometimes called Pustulosis palmaris et plantaris. It's characterized by small to large sterile blisters. [Source: NORD, GARD, Dermnetnz]
- Acute Generalized Exanthematous Pustulosis (AGEP): A rare, acute, severe skin reaction, mainly triggered by medications. It's characterized by the sudden appearance of tiny, non-follicular pustules on a reddened base. [Source: Medsafe, UpToDate, NCBI PMC]
- Pustular Psoriasis: A type of psoriasis resulting in skin plaques with pustules or blisters that can appear anywhere on the body. Palmoplantar pustulosis is considered a localized form of pustular psoriasis. [Source: Cleveland Clinic]
Key Characteristics
Regardless of the specific type, pustulosis generally shares these features:
- Pustules: The defining characteristic is the presence of numerous pustules (small, raised bumps filled with pus).
- Inflammation: Significant inflammation underlies the condition.
- Location: While PPP is specifically located on the palms and soles, other forms, such as AGEP, can spread across the entire body.
- Sterility (often): In many cases, the pustules are sterile, meaning they lack bacteria. This is notably true for PPP and AGEP.
Treatment
Treatment varies depending on the type and severity of pustulosis and is best determined by a dermatologist. Options may include topical medications, systemic therapies, and, in severe cases, phototherapy or other specialized treatments.
