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What causes high keratin in skin?

Published in Skin Conditions 1 min read

High keratin in skin, or hyperkeratosis, occurs when the body produces too much keratin, a tough, fibrous protein found in fingernails, hair, and skin. This excess keratin can cause the skin to thicken in certain places, resulting in patches of rough, thick skin.

Here are some common causes of high keratin in skin:

  • Inflammation: When the skin is inflamed, it may produce extra keratin as a protective mechanism.
  • Genetics: Some people are genetically predisposed to producing more keratin.
  • Skin conditions: Conditions like eczema, psoriasis, and keratosis pilaris can cause increased keratin production.
  • Allergies: Allergies can trigger inflammation, which can lead to hyperkeratosis.
  • Autoimmune diseases: Autoimmune diseases can cause inflammation and excessive keratin production.
  • Medications: Some medications can have hyperkeratosis as a side effect.
  • Sun exposure: Sun exposure can damage the skin and trigger increased keratin production.

Providers typically diagnose hyperkeratosis with a skin exam and biopsy.


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