The most permeable areas of human skin are the scrotum and ear lobe. These areas have a thinner stratum corneum, the outermost layer of the epidermis, which makes them more susceptible to the passage of substances. The face is another area with relatively high permeability, even varying within its different regions.
However, it's important to note that skin permeability is influenced by various factors, including the specific substance, the individual's age and health, and environmental conditions. The permeability of skin can change throughout the day, with some areas becoming more permeable during certain times.