The rarity of a skin depends heavily on the game in question. There's no single answer, as different games have different systems for determining rarity and different skins with varying availability.
Rarity in Video Games
Many online games, like Fortnite, Rainbow Six Siege, and Brawl Stars, feature cosmetic items called "skins." The rarity of these skins often reflects their limited availability and difficulty to obtain.
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Fortnite: The Aerial Assault Trooper skin is frequently cited as one of the rarest Fortnite skins. It was only available during Chapter 1 Season 1 and required reaching a specific level. [Source: 50 rarest Fortnite skins] Other extremely rare skins include the Renegade Raider.
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Rainbow Six Siege: The "Gold" skin in Rainbow Six Siege is considered "Rare" according to the in-game rarity system, similar to how "Black Ice" is "Epic". [Source: Is the gold skin considered rare?]
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Other Games: Rarity in other games, like Brawl Stars and Mobile Legends, is determined by various factors, including limited-time availability, in-game events, and overall distribution among players. Determining the rarest skin requires game-specific knowledge.
Rarity in Medical Context
The term "skin" can also refer to human skin. In this context, Merkel cell carcinoma is described as a very rare type of skin cancer. [Source: Types | Skin cancer | Cancer Research UK, Merkel cell carcinoma - Symptoms and causes - Mayo Clinic, What to Know About Merkel Cell Carcinoma, Jimmy Buffett's Rare...]