Yes, the lights surrounding the Grand Mosque and its holiest region, the Kaaba, are visible from space.
While the physical structure of the Kaaba itself is relatively small and dark, making direct observation challenging, the intense illumination surrounding the Grand Mosque makes the area distinguishable from space. This illumination is specifically designed and maintained, creating a stark contrast with the surrounding urban landscape at night. This contrast allows astronauts and satellites to identify the general location of the Kaaba even from hundreds of kilometers away.
In essence, it's not necessarily the Kaaba itself that's directly "seen", but rather the powerful lights emanating from the Grand Mosque which act as a beacon, marking the location of this significant religious site.