The primary injection used for treating ischemic stroke is recombinant tissue plasminogen activator (TPA).
Understanding TPA for Stroke
TPA is a thrombolytic (clot-busting) medication that can dissolve blood clots blocking blood flow to the brain during an ischemic stroke. According to available information, the two types of TPA used are alteplase (Activase) and tenecteplase (TNKase).
Types of TPA Injections
| Injection Name | Brand Name | Use in Stroke |
|---|---|---|
| Alteplase | Activase | Gold standard treatment for ischemic stroke, administered intravenously (IV). |
| Tenecteplase | TNKase | Alternative TPA, also administered intravenously (IV). |
How TPA Works
TPA works by activating plasminogen, which then converts to plasmin. Plasmin is an enzyme that breaks down fibrin, the main component of blood clots. By dissolving the clot, blood flow to the affected area of the brain is restored, reducing the risk of long-term damage.
