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Which Medicine is Best for Ear Sound?

Published in Tinnitus Treatment 3 mins read

The provided references list several medications that are not typically considered first-line treatments for ear sounds (tinnitus). However, these tricyclic antidepressants may sometimes be used, especially if the tinnitus is associated with underlying depression or anxiety.

It is important to note that there is no single "best" medicine for ear sounds (tinnitus), and treatment is highly individualized.


Understanding Tinnitus and Treatment Options

Tinnitus is the perception of sound when no external sound is present. It is more of a symptom than a disease in itself. The most effective treatment approach typically involves understanding and managing the underlying cause (if identified), habituation techniques and/or other therapies.


Tricyclic Antidepressants (TCAs) and Tinnitus

The following tricyclic antidepressants (TCAs) are listed in the provided references:


TCA Name Brand Name Notes
Clomipramine Anafranil May be used if co-existing depression/anxiety is present
Desipramine Norpramin May be used if co-existing depression/anxiety is present
Imipramine Tofranil May be used if co-existing depression/anxiety is present
Nortriptyline Pamelor May be used if co-existing depression/anxiety is present
Protriptyline Vivactil May be used if co-existing depression/anxiety is present



Important Considerations Regarding TCAs:

  • TCAs are generally not the first choice for tinnitus.
  • They are primarily used to treat depression and related mental health conditions, which can sometimes coexist with or exacerbate tinnitus.
  • Side effects of TCAs can include dry mouth, constipation, dizziness, and heart rhythm issues. Due to these side effects, they're generally considered a second or third line treatment.
  • The effectiveness of TCAs in reducing tinnitus is not consistent across all patients.
  • TCAs require a prescription and close monitoring by a physician.


Other Possible Approaches for Tinnitus:

  • Hearing aids: If hearing loss is present, amplification can often improve tinnitus.
  • Tinnitus Retraining Therapy (TRT): A habituation therapy that reduces the perceived loudness and distress associated with tinnitus.
  • Cognitive Behavioral Therapy (CBT): A psychological therapy that helps manage the emotional response to tinnitus.
  • Sound therapy: Using external sounds to mask tinnitus. This can include white noise, nature sounds, or customized sounds.
  • Treating Underlying conditions: Conditions such as Meniere's disease, temporomandibular joint (TMJ) disorder and thyroid problems may also contribute to tinnitus.
  • Medications: Some medications such as anti-anxiety medication or sleeping aids may be considered in certain cases. However, these medications should be used under medical supervision.

Seeking Professional Help

The correct course of action for dealing with ear sounds is to first see a medical professional to properly diagnose your condition and determine if any medical treatments are appropriate for you.


In summary, while tricyclic antidepressants like those listed (clomipramine, desipramine, imipramine, nortriptyline, and protriptyline) may sometimes be used if tinnitus is accompanied by mental health issues like depression, they are not generally considered the first-line treatment. A complete evaluation with a healthcare professional is essential for proper diagnosis and treatment plan.

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