Elevated Lactate Dehydrogenase (LDH) is a key characteristic found in patients with Thrombotic Thrombocytopenic Purpura (TTP).
Understanding LDH in TTP
In TTP, LDH levels are typically significantly higher than normal. The primary reason for this increase is due to the breakdown of red blood cells, which releases LDH into the bloodstream. This process of red blood cell destruction within the blood vessels is called intravascular hemolysis.
Key Points about LDH in TTP:
- Marker of Hemolysis: LDH serves as an indicator of intravascular hemolysis, a hallmark of TTP.
- Source of LDH: The primary source of the elevated LDH in TTP is the release from damaged red blood cells.
- Diagnostic Significance: Elevated LDH levels, in conjunction with other clinical findings such as thrombocytopenia and microangiopathic hemolytic anemia, aid in the diagnosis of TTP.
How LDH Levels Relate to TTP:
| Feature | Description |
|---|---|
| LDH | Elevated in TTP |
| Cause | Release from damaged red blood cells (intravascular hemolysis) |
| Diagnostic Use | Supports the diagnosis of TTP when combined with other signs and symptoms |
Why LDH is Important in TTP
The high level of LDH is crucial for diagnosing and monitoring TTP, as it reflects the extent of red blood cell damage occurring within the blood vessels. Monitoring LDH levels can also be helpful in tracking a patient’s response to treatment.
