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What is a Positive T-Spot Test?

Published in Tuberculosis Testing 2 mins read

A positive T-Spot TB test typically indicates that you have a Mycobacterium tuberculosis infection. This means that your body has been exposed to the bacteria that causes tuberculosis (TB) and your immune system has reacted to it.

However, a positive T-Spot test does not necessarily mean you have active TB disease. It primarily suggests either:

  • Latent TB Infection (LTBI): You have TB bacteria in your body, but your immune system is keeping it under control. You don't have symptoms and cannot spread the infection to others. Treatment is usually recommended to prevent the infection from becoming active TB disease.

  • Active TB Disease: The TB bacteria are actively multiplying in your body, causing symptoms like cough, fever, weight loss, and fatigue. You are contagious and require treatment to cure the disease and prevent further spread.

What Happens After a Positive T-Spot Test?

Because a positive T-Spot test can indicate either latent or active TB, further testing is necessary to determine the next steps. These tests typically include:

  • Chest X-ray: This imaging test helps to identify any signs of active TB disease in the lungs.

  • Sputum Tests: If the chest X-ray suggests active TB, sputum samples may be collected to test for the presence of TB bacteria.

Important Considerations:

  • False Positives: While less common than with the traditional TB skin test (TST), false-positive T-Spot results can occur.

  • False Negatives: Although T-Spot tests are generally more sensitive than TSTs, especially in people with weakened immune systems, false-negative results are still possible.

  • Consult a Healthcare Professional: It is crucial to discuss a positive T-Spot test result with a doctor for proper evaluation, diagnosis, and treatment recommendations. Self-diagnosis and treatment are strongly discouraged.

In summary, a positive T-Spot TB test means you likely have a TB infection (either latent or active), requiring further investigation to determine the specific course of action.

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