The most nephrotoxic antibiotic among the common aminoglycosides, according to the provided information, is neomycin.
Understanding Antibiotic Nephrotoxicity
Nephrotoxicity refers to damage to the kidneys caused by certain substances, in this case, antibiotics. Specifically, this type of kidney damage can occur with frequent, repeat dosing of certain antibiotics.
Why Does it Happen?
The provided reference indicates that nephrotoxicity with these antibiotics happens due to the increased accumulation of the antibiotic in the renal parenchyma, which is the functional tissue of the kidney. Frequent dosing leads to this buildup, potentially causing damage over time.
Ranking of Nephrotoxic Aminoglycosides
Aminoglycosides are a class of antibiotics known for their potential nephrotoxic effects. Based on the available information, these antibiotics can be ranked from most to least nephrotoxic:
- Neomycin: Identified as the most nephrotoxic.
- Gentamicin: Follows neomycin in terms of nephrotoxicity.
- Tobramycin: Ranked after gentamicin.
- Amikacin: Ranked after tobramycin.
- Streptomycin: Appears to be the least nephrotoxic among this group.
This ranking highlights that while all aminoglycosides carry a risk of nephrotoxicity, the degree of risk varies significantly among them, with neomycin posing the highest risk and streptomycin the lowest.
[Antibiotic Side Effects]
