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Do viruses use ribosomes?

Published in Virology 2 mins read

No, viruses do not have their own ribosomes; they hijack the ribosomes of the host cell to produce viral proteins.

How Viruses Exploit Host Ribosomes

Viruses, being obligate intracellular parasites, lack the cellular machinery necessary for independent protein synthesis. This means they cannot produce their own proteins without relying on a host cell. Ribosomes are essential for protein synthesis (translation), and viruses exploit the host cell's ribosomes to replicate themselves. The process involves:

  1. Infection: The virus infects a host cell.
  2. Genome Delivery: The viral genome (DNA or RNA) is introduced into the host cell.
  3. Ribosome Hijacking: The viral genome is transcribed (if necessary) to produce messenger RNA (mRNA). This viral mRNA then binds to the host cell's ribosomes.
  4. Viral Protein Synthesis: The host ribosomes, now directed by the viral mRNA, begin synthesizing viral proteins.
  5. Virus Assembly: These viral proteins are used to assemble new viral particles within the host cell.
  6. Release: The newly assembled viruses are released from the host cell to infect other cells.

Potential for Antiviral Therapies

Understanding precisely how viruses manipulate host cell ribosomes offers potential targets for antiviral drug development. By disrupting the interaction between viral mRNA and host ribosomes, or by targeting unique aspects of viral protein synthesis, novel antiviral therapies could be developed that specifically inhibit viral replication without significantly harming the host cell.

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