Determining the "greatest" virus of all time is subjective and depends on the criteria used. If we consider impact on human lives, the 1918 influenza pandemic, also known as the Spanish flu, is a strong contender. It infected an estimated 500 million people—about one-third of the world's population at the time—and killed 50 to 100 million. https://www.livescience.com/56598-deadliest-viruses-on-earth.html
However, if we consider the impact on computer systems, the answer changes. Several computer viruses have caused significant damage and disruption. For example:
- ILOVEYOU: This virus, released in 2000, caused widespread damage by spreading rapidly through email attachments. https://www.dsolutionsgroup.com/top-10-most-dangerous-malware-of-all-time/ It's often cited as one of the most infamous computer viruses. https://www.norton.com/blog/malware/famous-computer-viruses
- Melissa: First appearing in 1999, this virus spread through email, exploiting users' curiosity by offering access to adult websites. https://www.dsolutionsgroup.com/top-10-most-dangerous-malware-of-all-time/
- Code Red, Klez, Sobig, Mydoom, Sasser, and Zeus: These are other examples of significant computer viruses listed among the most dangerous. https://www.dsolutionsgroup.com/top-10-most-dangerous-malware-of-all-time/
Therefore, there's no single "greatest" virus. The answer depends on whether we consider biological viruses or computer viruses and the metrics used to measure their impact (mortality, economic damage, disruption).