The relationship between vitamin D and ferritin levels is complex and not consistently positive. While some studies show a positive association, others find no significant effect.
Studies Showing a Positive Association:
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An 8-Week Vitamin D3–Fortified Fruit Drink Supplementation Increases Serum Ferritin Concentration: This study demonstrated a significant increase in serum ferritin concentrations in a group supplemented with vitamin D3 compared to a placebo group. [Source: An 8-Week Vitamin D3–Fortified Fruit Drink Supplementation Increases Serum Ferritin Concentration: A Randomized Controlled Trial in Malaysian Women With Low Iron Stores]
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The Association Between Ferritin and Vitamin D Levels in ...: This research indicated a positive association between ferritin and vitamin D levels in premenopausal women with fibroid uteri and anemia. [Source: The Association Between Ferritin and Vitamin D Levels in Premenopausal Fibroid Uterus Cases With Anemia]
These studies suggest that vitamin D supplementation may lead to increased ferritin levels, particularly in individuals with low iron stores or specific conditions. However, the mechanism isn't fully understood; in iron deficiency anemia (IDA), it's suggested that vitamin D increases ferritin by down-regulating hepcidin. [Source: The association between serum ferritin and 25-hydroxyvitamin D ...]
Studies Showing No Significant Effect:
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The effect of vitamin D supplementation on hemoglobin ...: This review concluded that vitamin D supplementation did not significantly impact ferritin levels. [Source: The effect of vitamin D supplementation on hemoglobin and ferritin levels in adults: a systematic review and meta-analysis]
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Effect of vitamin D3 supplementation on iron status: a randomized ...: This study found that vitamin D3 supplementation over 16 weeks did not improve serum ferritin levels. [Source: Effect of vitamin D3 supplementation on iron status: a randomized controlled trial]
Conclusion:
The effect of vitamin D on ferritin levels is not definitive. While some studies suggest a positive correlation, particularly in specific populations, others have not found a significant relationship. More research is needed to fully understand this complex interaction.
