There isn't a single "weakest" part of the male body, as vulnerability depends on the context (e.g., self-defense, injury susceptibility). However, several areas are significantly more vulnerable than others.
Highly Vulnerable Areas:
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Testicles: As stated on Twitter by Dr. Stacey Patton, "Male testicles are the most vulnerable & weakest part of the male anatomy." A blow to this area causes intense pain and can result in temporary or permanent incapacitation.
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Groin: A kick to the groin ("Kick the groin") is a well-known self-defense technique due to its high effectiveness. The concentration of sensitive nerves and blood vessels makes this area extremely vulnerable.
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Eyes: Poking the eyes is another effective self-defense technique mentioned in "Human Weak Points for Self-Defence" because of their sensitivity.
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Throat: A strike to the throat ("Punch to the throat") can severely restrict breathing and cause immediate incapacitation.
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Temples: The temples are a vulnerable area of the skull, as noted in various sources. A blow to the temples can cause serious brain injury.
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Nose: Breaking the nose ("Breaking the nose") is another effective self-defense technique because of the concentration of nerves and blood vessels in this area.
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Other Vulnerable Areas: The jaw ("JAW"), solar plexus ("SOLAR PLEXUS"), ribs ("RIBS"), knees ("KNEES"), shins ("SHIN"), and toes ("CRUSH THE TOES") are also considered vulnerable areas, but their vulnerability varies depending on the type of attack. For instance, "A rib is most likely to fracture at its outer curve, which is its weakest point."
Conclusion
The question's premise is somewhat flawed; there isn't a single weakest point. Vulnerability depends heavily on the type of attack and the individual's resilience. However, the testicles are frequently cited as the most vulnerable area due to their sensitivity and exposed location.