In Wilson's disease, ceruloplasmin is affected because copper is not properly attached to it.
Here's a more detailed explanation:
Ceruloplasmin's primary function is to carry copper throughout the body to tissues that require it. However, in individuals with Wilson's disease, a genetic disorder, this process is disrupted. Specifically, copper is not put in ceruloplasmin. This disruption, combined with the liver's inability to eliminate excess copper through bowel movements, leads to a copper buildup in the liver. Eventually, the excess copper overflows into the bloodstream, causing damage to various organs, including the brain, liver, and eyes.
| Feature | Normal Function | Wilson's Disease |
|---|---|---|
| Ceruloplasmin | Carries copper to tissues. | Copper is not properly bound to ceruloplasmin. |
| Copper excretion | Excess copper eliminated through bowel movements. | Liver fails to excrete excess copper effectively. |
| Copper levels | Copper levels remain balanced. | Copper accumulates in the liver and blood. |
